Kindly clarify. Thanks Sundar Edit: Category changed.Dif-tor heh smusma Helmut Schtz The quality of responses received is directly proportional to the quality of the question asked.Kindly guide me can we do f2 calculation using this data, i.e.IMHO, you should find a different test to compare your products.
Whereas, in phosphate binding in-vitro study mean phosphate binding profile will be generated based on the initial phosphate concentration in the solution and not related to the time. The formula and procedure to obtain f2 value is described in one of the publications. An average difference of 10 at all measured time points results in a f2 value of 50. A public standard of f2 value between 50-100 to indicate similarity between two dissolution profiles. Another way of saying this is that on average if difference at each sampling time is 10 or less then f2 value will be between 50 and 100. Therefore, a quick way to establish similarly of two profiles is to see if differences in dissolution results at each sampling time are less than 10. At best, the parameter (f2) appears to be a rule-of-thumb type gauge, and perhaps appears to add some extra burden for evaluating and reporting dissolution results without real gain in data analysis. However, f2 which in general is suggested for evaluating products with formulationmanufacturing differences (for product developments andor alterations), the allowance should be greater, thus wider range with a lower cut-off value than 50 may be more appropriate.
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